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web3.py is a Python library for interacting with Ethereum. It’s commonly found in decentralized apps (dapps) to help with sending transactions, interacting with smart contracts, reading block data, and a variety of other use cases. Point web3.py at Node RPC to reach 80+ EVM networks, and see the JSON-RPC reference for supported methods.
connect.py

from web3 import Web3, AsyncWeb3

w3 = Web3(Web3.HTTPProvider('https:// mainnet.gateway.tenderly.co/<TENDERLY_NODE_ACCESS_KEY_MAINNET>'))
w3Async = AsyncWeb3(AsyncWeb3.AsyncHTTPProvider('https:// mainnet.gateway.tenderly.co/<TENDERLY_NODE_ACCESS_KEY_MAINNET>'))
w3Wss = Web3(Web3.WebsocketProvider('wss:// mainnet.gateway.tenderly.co/<TENDERLY_NODE_ACCESS_KEY_MAINNET>'))

print(w3.eth.get_block('latest'))
print(w3Async.eth.get_block('latest'))
print(w3Wss.is_connected())
print(w3Wss.eth.get_block('latest'))