Here you'll find examples showing how to utilize Tenderly to achieve testing against actual Mainnet data with ease, while integrating other capabilities of Tenderly in your testing process, with no need for a local node.
Local tests on top of Mainnet data in the Cloud gives a high-level overview of running your local tests against Mainnet data.
Here you can find a very basic first usage of Tenderly API in tests, where transactions performed by your tests are simulated on a Tenderly Fork behind the scenes.
The following how-to list might give you more ideas about everything that is possible to test with Tenderly: order to test the contract. order to optimize test suite run-time. order to isolate individual tests in a test suite.
The code for these examples can be found in this GitHub repo.